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Träfflista för sökning "WFRF:(Kremen William S.) ;pers:(Kaprio Jaakko);hsvcat:5"

Search: WFRF:(Kremen William S.) > Kaprio Jaakko > Social Sciences

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1.
  • Silventoinen, Karri, et al. (author)
  • Education in twins and their parents across birth cohorts over 100 years : an individual-level pooled analysis of 42 twin cohorts
  • 2017
  • In: Twin Research and Human Genetics. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 1832-4274 .- 1839-2628.
  • Journal article (peer-reviewed)abstract
    • Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990-1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
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2.
  • Reynolds, Chandra A., et al. (author)
  • Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood : Is APOE a Variability Gene?
  • 2016
  • In: Behavior Genetics. - : Springer Nature Switzerland AG. - 0001-8244 .- 1573-3297. ; 46:1, s. 4-19
  • Journal article (peer-reviewed)abstract
    • Despite emerging interest in gene-environment interaction (GxE) effects, there is a dearth of studies evaluating its potential relevance apart from specific hypothesized environments and biometrical variance trends. Using a monozygotic within-pair approach, we evaluated evidence of G×E for body mass index (BMI), depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries. We also evaluated whether APOE is a 'variability gene' across these measures and whether it partly represents the 'G' in G×E effects. In all three domains, G×E effects were pervasive across country and gender, with small-to-moderate effects. Age-cohort trends were generally stable for BMI and depressive symptoms; however, they were variable-with both increasing and decreasing age-cohort trends-for different cognitive measures. Results also suggested that APOE may represent a 'variability gene' for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures. Hence, additional genes are salient beyond APOE.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Pedersen, Nancy L (2)
Kaprio, Jaakko (2)Undo refine
Gatz, Margaret (2)
Kremen, William S. (2)
McGue, Matt (2)
Hopper, John L. (1)
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Lichtenstein, Paul (1)
Almqvist, Catarina (1)
Tynelius, Per (1)
Magnusson, Patrik K ... (1)
Latvala, Antti (1)
Willemsen, Gonneke (1)
Korhonen, Tellervo (1)
Martin, Nicholas G. (1)
Boomsma, Dorret I. (1)
Rebato, Esther (1)
Ullemar, Vilhelmina (1)
Rasmussen, Finn (1)
Sorensen, Thorkild I ... (1)
Tuvblad, Catherine, ... (1)
Montgomery, Grant W. (1)
Loos, Ruth J F (1)
Dahl Aslan, Anna K., ... (1)
Maes, Hermine H. (1)
Baker, Laura A. (1)
Buchwald, Dedra (1)
Dahl Aslan, Anna K. (1)
Reynolds, Chandra A. (1)
Turkheimer, Eric (1)
Christensen, Kaare (1)
Franz, Carol E. (1)
Whitfield, Keith E. (1)
Medland, Sarah E (1)
Bartels, Meike (1)
Tucker-Drob, Elliot ... (1)
Cozen, Wendy (1)
Harris, Jennifer R. (1)
van Beijsterveldt, C ... (1)
Burt, S. Alexandra (1)
Klump, Kelly L (1)
Mack, Thomas M. (1)
Zhang, Dongfeng (1)
Pang, Zengchang (1)
Tan, Qihua (1)
Colodro-Conde, Lucia (1)
Silventoinen, Karri (1)
Koskenvuo, Markku (1)
Pahlen, Shandell (1)
Krueger, Robert F. (1)
Sumathipala, Athula (1)
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University
Jönköping University (2)
University of Skövde (2)
Karolinska Institutet (2)
Örebro University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Social Sciences (2)Undo refine
Natural sciences (1)

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